This paper generalizes classical spin geometry to the setting of weighted manifolds and provides applications to the Ricci flow. Spectral properties of the naturally associated weighted Dirac operator, introduced by Perelman, and its relationship with the weighted scalar curvature are investigated. Further, a generalization of the ADM mass for weighted asymptotically Euclidean (AE) manifolds is defined; on manifolds with nonnegative weighted scalar curvature, it satisfies a weighted Witten formula and thereby a positive weighted mass theorem. Finally, it is shown that on AE manifolds with nonnegative scalar curvature, Ricci flow is the gradient flow of said weighted ADM mass, for a natural choice of weight function. This yields a monotonicity formula for the weighted spinorial Dirichlet energy of a weighted Witten spinor along Ricci flow.