Water movement in biological tissue is controlled primarily by osmosis, and the main osmolytes are ions (Na, K, Cl etc). It is then natural to speculate that electrophysiology is in some way related to cell movement. This indeed seems to be the case; there is increasing evidence that ion channels and aquaporins play an important role in cell movement. In this talk, we will first review some classical facts about electrophysiology, focusing on its role in cell volume control. We will also discuss the classical subject of fluid secretion/absorption in epithelial systems, and compare this with recent work on a mode of cell movement that seems to be predominantly osmotic. We will then present a mathematical framework that couples electrophysiology, osmosis and cell mechanics in a natural way that allows for the study of this interplay. We will show preliminary 2D computational results of a deforming model cell moving using osmotic forces. This is joint work with Linxing Yao. This work was supported by NSF-DMS 1620316.